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Vitamin B12 deficiency can occur through insufficient diet (e.g., un-supplemented veganism or absorption issues (e.g., pernicious anaemia) Treatment for B12 deficiency is regular intramuscular injections until symptoms improve

DOI: 10.1080/15563650.2019.1606432 Aroda VR et al, "Long-term metformin use and vitamin B12 deficiency in the Diabetes Prevention Program Outcomes Study." Journal of Clinical Endocrinology and Metabolism, Feb

The skin and the muscles under the skin cover nerves, blood vessels and bones

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Suspected adverse reactions should be reported through the MHRA Yellow Card scheme